Preexisting CD4+ T-Cell Immunity in Human Population to Avian Influenza H7N9 Virus: Whole Proteome-Wide Immunoinformatics Analyses
Identifieur interne : 000688 ( Main/Exploration ); précédent : 000687; suivant : 000689Preexisting CD4+ T-Cell Immunity in Human Population to Avian Influenza H7N9 Virus: Whole Proteome-Wide Immunoinformatics Analyses
Auteurs : Venkata R. Duvvuri [Canada] ; Bhargavi Duvvuri [Canada] ; Christilda Alice [Canada] ; Gillian E. Wu [Canada] ; Jonathan B. Gubbay [Canada] ; Jianhong Wu [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Allèles, Animaux, Biologie informatique, Chine, Déterminants antigéniques des lymphocytes T (immunologie), Grippe chez les oiseaux (immunologie), Groupes ethniques, Humains, Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Oiseaux (immunologie), Oiseaux (virologie), Protéines membranaires (métabolisme), Protéome (immunologie), Similitude de séquences d'acides aminés, Sous-type H7N9 du virus de la grippe A (immunologie), Séquence conservée.
- MESH :
- immunologie : Déterminants antigéniques des lymphocytes T, Grippe chez les oiseaux, Lymphocytes T CD4+, Lymphocytes T CD8+, Oiseaux, Protéome, Sous-type H7N9 du virus de la grippe A.
- métabolisme : Protéines membranaires.
- virologie : Oiseaux.
- Allèles, Animaux, Biologie informatique, Chine, Groupes ethniques, Humains, Similitude de séquences d'acides aminés, Séquence conservée.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Alleles, Animals, Birds (immunology), Birds (virology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), China, Computational Biology, Conserved Sequence, Epitopes, T-Lymphocyte (immunology), Ethnic Groups, Humans, Influenza A Virus, H7N9 Subtype (immunology), Influenza in Birds (immunology), Membrane Proteins (metabolism), Proteome (immunology), Sequence Homology, Amino Acid.
- MESH :
- chemical , immunology : Epitopes, T-Lymphocyte, Proteome.
- chemical , metabolism : Membrane Proteins.
- geographic : China.
- immunology : Birds, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Influenza A Virus, H7N9 Subtype, Influenza in Birds.
- virology : Birds.
- Alleles, Animals, Computational Biology, Conserved Sequence, Ethnic Groups, Humans, Sequence Homology, Amino Acid.
Abstract
In 2013, a novel avian influenza H7N9 virus was identified in human in China. The antigenically distinct H7N9 surface glycoproteins raised concerns about lack of cross-protective neutralizing antibodies. Epitope-specific preexisting T-cell immunity was one of the protective mechanisms in pandemic 2009 H1N1 even in the absence of cross-protective antibodies. Hence, the assessment of preexisting CD4+ T-cell immunity to conserved epitopes shared between H7N9 and human influenza A viruses (IAV) is critical. A comparative whole proteome-wide immunoinformatics analysis was performed to predict the CD4+ T-cell epitopes that are commonly conserved within the proteome of H7N9 in reference to IAV subtypes (H1N1, H2N2, and H3N2). The CD4+ T-cell epitopes that are commonly conserved (∼556) were further screened against the Immune Epitope Database (IEDB) to validate their immunogenic potential. This analysis revealed that 45.5% (253 of 556) epitopes are experimentally proven to induce CD4+ T-cell memory responses. In addition, we also found that 23.3% of CD4+ T-cell epitopes have ≥90% of sequence homology with experimentally defined CD8+ T-cell epitopes. We also conducted the population coverage analysis across different ethnicities using commonly conserved CD4+ T-cell epitopes and corresponding HLA-DRB1 alleles. Interestingly, the indigenous populations from Canada, United States, Mexico and Australia exhibited low coverage (28.65% to 45.62%) when compared with other ethnicities (57.77% to 94.84%). In summary, the present analysis demonstrate an evidence on the likely presence of preexisting T-cell immunity in human population and also shed light to understand the potential risk of H7N9 virus among indigenous populations, given their high susceptibility during previous pandemic influenza events. This information is crucial for public health policy, in targeting priority groups for immunization programs.
Url:
DOI: 10.1371/journal.pone.0091273
PubMed: 24609014
PubMed Central: 3946744
Affiliations:
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Le document en format XML
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type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Mount Sinai Hospital, Toronto, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jianhong" sort="Wu, Jianhong" uniqKey="Wu J" first="Jianhong" last="Wu">Jianhong Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Disease Modelling, York Institute of Health Research, Toronto, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Disease Modelling, York Institute of Health Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>York University, Toronto, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>York University, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Animals</term><term>Birds (immunology)</term><term>Birds (virology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>China</term><term>Computational Biology</term><term>Conserved Sequence</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Ethnic Groups</term><term>Humans</term><term>Influenza A Virus, H7N9 Subtype (immunology)</term><term>Influenza in Birds (immunology)</term><term>Membrane Proteins (metabolism)</term><term>Proteome (immunology)</term><term>Sequence Homology, Amino Acid</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term><term>Animaux</term><term>Biologie informatique</term><term>Chine</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Grippe chez les oiseaux (immunologie)</term><term>Groupes ethniques</term><term>Humains</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Oiseaux (immunologie)</term><term>Oiseaux (virologie)</term><term>Protéines membranaires (métabolisme)</term><term>Protéome (immunologie)</term><term>Similitude de séquences d'acides aminés</term><term>Sous-type H7N9 du virus de la grippe A (immunologie)</term><term>Séquence conservée</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Proteome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes T</term><term>Grippe chez les oiseaux</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term><term>Oiseaux</term><term>Protéome</term><term>Sous-type H7N9 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Birds</term><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Influenza A Virus, H7N9 Subtype</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines membranaires</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Oiseaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Birds</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Animals</term><term>Computational Biology</term><term>Conserved Sequence</term><term>Ethnic Groups</term><term>Humans</term><term>Sequence Homology, Amino Acid</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Animaux</term><term>Biologie informatique</term><term>Chine</term><term>Groupes ethniques</term><term>Humains</term><term>Similitude de séquences d'acides aminés</term><term>Séquence conservée</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In 2013, a novel avian influenza H7N9 virus was identified in human in China. The antigenically distinct H7N9 surface glycoproteins raised concerns about lack of cross-protective neutralizing antibodies. Epitope-specific preexisting T-cell immunity was one of the protective mechanisms in pandemic 2009 H1N1 even in the absence of cross-protective antibodies. Hence, the assessment of preexisting CD4+ T-cell immunity to conserved epitopes shared between H7N9 and human influenza A viruses (IAV) is critical. A comparative whole proteome-wide immunoinformatics analysis was performed to predict the CD4+ T-cell epitopes that are commonly conserved within the proteome of H7N9 in reference to IAV subtypes (H1N1, H2N2, and H3N2). The CD4+ T-cell epitopes that are commonly conserved (∼556) were further screened against the Immune Epitope Database (IEDB) to validate their immunogenic potential. This analysis revealed that 45.5% (253 of 556) epitopes are experimentally proven to induce CD4+ T-cell memory responses. In addition, we also found that 23.3% of CD4+ T-cell epitopes have ≥90% of sequence homology with experimentally defined CD8+ T-cell epitopes. We also conducted the population coverage analysis across different ethnicities using commonly conserved CD4+ T-cell epitopes and corresponding HLA-DRB1 alleles. Interestingly, the indigenous populations from Canada, United States, Mexico and Australia exhibited low coverage (28.65% to 45.62%) when compared with other ethnicities (57.77% to 94.84%). In summary, the present analysis demonstrate an evidence on the likely presence of preexisting T-cell immunity in human population and also shed light to understand the potential risk of H7N9 virus among indigenous populations, given their high susceptibility during previous pandemic influenza events. This information is crucial for public health policy, in targeting priority groups for immunization programs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Xiao, H" uniqKey="Xiao H">H Xiao</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Cui, D" uniqKey="Cui D">D Cui</name></author><author><name sortKey="Yao, H" uniqKey="Yao H">H Yao</name></author><author><name sortKey="Lou, J" uniqKey="Lou J">J 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first="Venkata R." last="Duvvuri">Venkata R. Duvvuri</name></noRegion><name sortKey="Alice, Christilda" sort="Alice, Christilda" uniqKey="Alice C" first="Christilda" last="Alice">Christilda Alice</name><name sortKey="Duvvuri, Bhargavi" sort="Duvvuri, Bhargavi" uniqKey="Duvvuri B" first="Bhargavi" last="Duvvuri">Bhargavi Duvvuri</name><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B." last="Gubbay">Jonathan B. Gubbay</name><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B." last="Gubbay">Jonathan B. Gubbay</name><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B." last="Gubbay">Jonathan B. Gubbay</name><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B." last="Gubbay">Jonathan B. Gubbay</name><name sortKey="Wu, Gillian E" sort="Wu, Gillian E" uniqKey="Wu G" first="Gillian E." last="Wu">Gillian E. Wu</name><name sortKey="Wu, Jianhong" sort="Wu, Jianhong" uniqKey="Wu J" first="Jianhong" last="Wu">Jianhong Wu</name><name sortKey="Wu, Jianhong" sort="Wu, Jianhong" uniqKey="Wu J" first="Jianhong" last="Wu">Jianhong Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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